The influence of neuroamines on the oxidation of glucose by the anterior pituitary. I. The role of monoamine oxidase.

It has been reported (1) that epinephrine, norepinephrine, and serotonin stimulate the oxidation of the first but not the sixth carbon atoms of glucose by beef anterior pituitary slices and rat cerebral cortical fragments. It is shown here that this effect on glucose oxidation is also exerted by other amines which are substrates of monoamine oxidase and that inhibitors of monoamine oxidase block this effect of the amines. The stimulatory effect of aldehydes on glucose-l-C14 oxidation by beef anterior pituitary slices is also demonstrated.